Home CBD Education CBD Oil Side Effects, Interactions, What We Know And Don’t Know.

CBD Oil Side Effects, Interactions, What We Know And Don’t Know.

CBD Oil Side Effects, Interactions, What We Know And Don’t Know.

Although CBD is well-tolerated by the vast majority of users, as with most supplements, some people may experience mild side-effects. There are also certain groups of people advised not to take CBD, or only to do so under their physician’s guidance.

In this five minute guide, we’ll provide a brief history of CBD before diving into the evidence of side effects and the potential dangers of taking counterfeit CBD products. 

We’ll also discuss the contraindications relating to several conditions and situations that CBD use could effect.

By the end of this article, you’ll have gained knowledge around who shouldn’t take CBD oil, and why it’s vital to ensure that you purchase a genuine and safe CBD product.

CBD: A Brief History

The origins of Cannabidiol (CBD) can be traced as far back as the end of the first ice age. We can tell from archeological studies that Cannabis Sativa, the source plant for CBD, was one of the first crops planted by our ancestors.

To dig a little deeper, Carl Sagan stated that Cannabis could well have been the world’s first agricultural crop, helping to develop civilization itself. If we study the timelines carefully, it’s evident that cannabis plants have been an integral part of human culture for thousands of years.

Food and Materials

Hemp ShoesThroughout history, cannabis plants have been praised for their versatility. Cannabis seeds and oil were used by the Chinese as long ago as 6,000 BCE. Fast forward 2000 years, and you’ll find evidence that textiles crafted from hemp plants were utilized in Turkestan and China.

The influence of the hemp plant spread across the world. By the year 850AD, the Vikings were transporting hemp seeds and ropes to Iceland. Fifty years later, Arabs started to make paper from hemp materials. As recently as the year 1000, Italian sailors were using hemp ropes to navigate the oceans.

Changing Legislation

When we think of today’s restrictions on growing Cannabis, it’s hard to believe that just 500 years ago, it was illegal not to cultivate hemp in Virginia. The plant was so famous for industrial use; it became compulsory for farmers to grow hemp. 

In the year 1850, Cannabis was added to the U.S. Pharmacopeia, a widely respected compendium of dietary supplements and medicines. That same year, Cannabis was promoted and used across the USA as a medicinal drug that could be bought from general stores and pharmacies up until 1915.

Turning Tides

According to the North American Industrial Hemp Council (NAIHC), the cultivation of Cannabis Sativa, for industrial or recreational purposes, has been prohibited in the USA since the mid-1950s.

However, all of this is beginning to change. The global explosion of interest in compounds derived from hemp, such as CBD, has lead to lobbying efforts from farmers and advocates throughout America.

On December 12th, 2019, congress legalized hemp at a federal level as they passed the 2018 Farm Bill. This created a market that’s expected to boom by 2022.

The Side Effects of CBD

With the rise in popularity of CBD oil use, we want to provide you with all the information available regarding possible adverse side effects and scientific evidence. In the following sections, we’ll explain the various side effects that you could encounter when using CBD, what they mean, and what recent research suggests around taking CBD if you are:

  • Pregnant
  • Trying to conceive
  • Immune-compromised
  • Taking prescription medications.
  • Breastfeeding
  • And more….

CBD Oil: The Clinical Evidence

It’s a fact; there is very little definitive clinical evidence related to CBD concerning many ailments.

Perhaps one of the most documented breakthroughs regarding FDA-approved prescription CBD treatment is the introduction of ‘Epidiolex’ to the U.S. medical market. This oral-solution is used to treat two rare forms of childhood epilepsy, with CBD working as one of the main active ingredients.

However, to collect significant clinical evidence to support FDA-approval, Epidiolex’s manufacturers had to fund clinical research and trials for almost twenty years.

That said, the approval of this drug has opened the doors for the wider global medical community’s acceptance of CBD. With the U.S. medical system structure relying on costly clinical testing, the majority of tests are funded by organizations that plan to patent drugs and profit from their sale.

That leaves us with a vast amount of preliminary scientific evidence discovered via case studies, animal models, and laboratory experiments. Every year, hundreds of studies are Updated around CBD. This evidence is what helps the industry advance towards more efficient clinical trials.

Currently, there are over 40 CBD-related trials active or recruiting participants for a variety of conditions. The number of tests being undertaken is steadily increasing every year, which could mean that some of CBD’s most promising benefits may be confirmed or denied.

It could be many years before accredited clinical evidence to support CBD’s ability to alleviate certain conditions is Updated. However, thousands of people supplement with CBD anyway, hoping that they won’t have to wait many years to find out if CBD could be useful for their conditions.

CBD Side Effects: Evidence from High-Dose Clinical Trials

There has been no conclusive evidence to suggest serious side effects from the few clinical trials conducted using CBD.

We need to look back through the vast research funded and conducted for Epidolex research to study long-term results.

Throughout clinical trials for this drug, participants aged between 2 and 18 were administered large doses of CBD for 14 weeks. Each day a dose equivalent to 1,360mg for a 150-pound adult was taken. This dosage is similar to the amount of CBD present in a whole bottle of CBD oil.

The most frequently reported side effects included:

  • Decreased appetite
  • Gastrointestinal issues
  • Fatigue
  • Altered liver enzymes (more about this below)

Most of the participants’ side effects occurred during the early weeks of the trial when the dosage increased rapidly. Typically, these symptoms subsided once the CBD dosage was stabilized. Therefore, lowering the dose was seen as an effective way to decrease harmful side effects.

If you currently take CBD and have experienced any of these adverse reactions, we recommend lowering your dose or taking a break for a week. If the side effects fail to subside, you may want to try a different type of CBD product.

If you’re taking unusually large doses of CBD, you can access the Epidolex clinical trials document here. This may provide more detailed insights into high-dose CBD side effects and how to decrease their occurrence.

Possible Side Effects from Counterfeit or Poor-Quality CBD Products

When we consider the side-effects in the Epidiolex trials, we must remember that these trials used safe products that contained reliable quantities of CBD.

Therefore, the side effects revealed by the trial could be expected if you’re taking very high doses of an incredibly pure CBD product. 

However, due to the lack of regulation for the U.S. supplement industry, there are hundreds of counterfeit and dishonest manufacturers selling CBD products online. If you buy CBD products from these manufacturers, you could experience a range of different side-effects.

In fact, a 2017 survey revealed that after testing a range of publicly available CBD products, just 31% were labeled accurately. We cannot stress enough the importance of sourcing your CBD from a professional company that regularly encourages third-party laboratory testing and organic purity.

Potentially harmful ingredients in ‘CBD Products’ could include:

  • Heavy metals, bacteria, molds, and aflatoxins; which are substances that can affect the body in a similar way to pesticides.
  • Contaminants such as metal particles and pesticides; These substances can make people very sick and could prove fatal if present in large quantities.
  • 5F-ADB: This is usually present in synthetic marijuana products such as ‘Spice’ or ‘K2’ and can cause hallucinations, paranoia, anxiety, vomiting, chest pain, and seizures. Large quantities of 5F-ADB can lead to organ failure and death.
  • THC: Although some CBD products contain tiny trace amounts of THC, fake products may contain significant amounts. These can cause anxiety and hallucinations.
  • Alcohol-based solvent residue: CBD oils that are made with hexane, ethanol, butane, or isopropyl can leave residues that pose a severe health hazard.
  • OTC cough medication: Some CBD products sold by haphazard suppliers have been found to contain dextromethorphan. This ingredient is common in OTC cough medications and can cause intense periods of drowsiness.

Failing Drug Tests:

There’s a chance you could fail a drug test if you purchase and consume CBD oils that contain detectable levels of THC or artificial cannabinoids.

Thousands of people are required to take these tests as part of their employment or training contracts. Therefore, you must remember that anything over 0.3% THC content of the total CBD oil extract may be detected in a drug test.

Professionally manufactured CBD products are processed using hemp plants, which could contain small quantities of THC if it’s not removed during the extraction process. If your CBD product contains large amounts of THC, you could notice side effects such as hunger, dry mouth, and mood alterations.

It’s worth considering that the most adverse effects of bogus CBD products could lead to long-term damage to your body that is not immediately apparent.

Therefore, if you’re concerned about the legitimacy of your current CBD products, throw them away. CBD oil is a concentrated plant-based supplement that interacts with your body – so you want it to match the quality of the foods you eat.


We hope that this piece offered you a comprehensive guide to some of the side effects that CBD could cause if taken regularly. We want to provide all Avida customers with additional support covering critical topics related to CBD. 

If you have any concerns relating to CBD and its contraindications or side effects, we always recommend seeking the advice of a professional medical practitioner. If you suspect that the CBD product you are taking may be counterfeit, throw it away and look for a verified and legitimate manufacturer. Your health and wellbeing is never worth compromising.


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